Overview of Selected Chemical Compounds and Intermediates

Overview of Selected Chemical Compounds and Intermediates

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one. Pharmaceutical Intermediates
Bortezomib Acid Impurity: This is certainly an impurity connected with bortezomib, a proteasome inhibitor used in the treatment of a number of myeloma. Its synthesis or examine is very important for making certain the purity and safety in the drug.
Abiraterone Acetate Intermediate (CAS NO. 122111-01-seven): A precursor during the synthesis of abiraterone acetate, a drug Utilized in the cure of prostate most cancers by inhibiting androgen creation.
Imatinib Intermediate (CAS NO. 152460-10-one): A essential compound inside the synthesis of imatinib, a drug that targets specific types of most cancers, which includes chronic myelogenous leukemia (CML).
Docetaxel Intermediate: A compound Employed in the synthesis of docetaxel, a chemotherapy medication that treats numerous cancers which include breast, lung, and prostate cancer.
two. Chemical Impurities and Byproducts
GeMcitabine Intermediates (T6, T9, 8): They are intermediates during the synthesis of gemcitabine, an anti-most cancers drug. Their study is significant for optimizing the manufacturing course of action and ensuring superior purity.
Lapatinib Intermediate (CAS NO. 231278-eighty four-5): Lapatinib is utilized to deal with breast most cancers, and these intermediates are linked to its production.
Fulvestrant Intermediates: Fulvestrant can be an estrogen receptor antagonist Utilized in the therapy of breast cancer. Various intermediates assist in the synthesis of the drug.
Paclitaxel Side Chain Acid (CAS NO. 949023-sixteen-9): This intermediate is used in the synthesis of paclitaxel, a chemotherapy drug helpful in dealing with cancers which include ovarian, breast, and lung cancer.
3. Other Notable Compounds
Irinotecan Hydrochloride Trihydrate (CAS NO. 136572-09-three): A chemotherapy drug Employed in the treatment of colorectal most cancers and compact mobile lung cancer.
3-Amino-one-hydroxyadamantane (CAS 702-82-9): This compound is linked to the synthesis of adamantane derivatives, that have various applications, which includes antiviral Attributes.
Vildagliptin Intermediates: Used in the creation of vildagliptin, an oral drug hydrochloride for sort two diabetic issues that inhibits the enzyme DPP-four to regulate blood sugar ranges.
4. Miscellaneous Compounds
D-Gluconic Acid δ-Lactone (CAS NO. 61259-48-one): This compound is linked to the 5-dibenzoate-1-methanesulfonate synthesis of varied gluconic acid derivatives, which can be used in foodstuff, pharmaceutical, and industrial apps.
Canagliflozin Intermediate 2: A precursor while in the synthesis of canagliflozin, a medication employed to manage type 2 diabetes by inhibiting sodium-glucose co-transporter two (SGLT2).